Opportunity Information: Apply for HT9425 23 NFRP EHDA
The Department of Defense Neurofibromatosis Research Program (NFRP) Exploration - Hypothesis Development Award is designed to fund early-stage, high-risk research ideas in neurofibromatosis (NF) that could open up entirely new directions for the field. The core intent is to support projects that are exploratory and potentially groundbreaking, where the main outcome is a strong foundation for future, more extensive studies rather than a fully mature, late-stage research program. Applicants are expected to propose a clearly stated and testable hypothesis supported by a solid scientific rationale and a study design that can credibly evaluate that hypothesis. A notable feature of this mechanism is that preliminary or published supporting data are not required, which makes it especially suitable for investigators pursuing novel concepts that are not yet well established.
Innovation is a central requirement. The program is looking for ideas that introduce new paradigms, challenge existing assumptions, or tackle NF-related problems from genuinely new angles. Projects that mainly extend prior work in a straightforward or incremental way are not viewed as a good fit. Because of this, the Principal Investigator needs to explicitly explain what makes the approach innovative within NF research and why the question or method could produce high-impact gains if successful, even if the work carries substantial uncertainty.
Data sharing and research transparency are also built into the expectations for awardees. Recipients will be expected to share data in line with the FAIR Data Principles, meaning research outputs should be findable, accessible, interoperable, and reusable to support reproducible science. Applicants are directed to follow the program's Data and Research Resources Sharing Plan guidance (referenced as Attachment 8 in the opportunity materials), signaling that planning for how data and resources will be managed and shared is part of responsible project execution under this award.
For projects involving human subjects or related materials requiring oversight, there is a specific compliance constraint: studies must qualify for Institutional Review Board (IRB) exempt or expedited review status under applicable federal regulations (including 32 CFR 219.104(d) for exempt categories and 21 CFR 56.110 for expedited review). Proposals that require full board IRB review (that is, do not meet exempt or expedited criteria) will be administratively withdrawn, so applicants need to confirm early that their planned work fits within these review pathways and aligns with their institution's IRB policies.
From an administrative and funding-structure perspective, awards are issued as assistance agreements, meaning the government is providing support to advance a public purpose rather than procuring a service for direct government use. Depending on how much programmatic involvement the Department of Defense anticipates during the project, the award may be made either as a grant (when no substantial involvement is expected) or as a cooperative agreement (when substantial involvement is expected, such as collaboration or active participation during performance). The specific mechanism and start date are finalized during negotiations.
In the published opportunity details, the sponsoring agency is the Department of Defense, Department of the Army (USAMRAA). The opportunity number is HT9425 23 NFRP EHDA, listed under CFDA 12.420, and eligibility is described as unrestricted (open broadly to entity types, subject to any additional clarifications in the full announcement). The posting anticipated about five awards. The original application closing date was August 25, 2023 (created May 22, 2023). The listing shows an award ceiling of 0, which typically indicates the ceiling is not specified in the public summary and would need to be confirmed in the full program announcement or associated budget guidance.Apply for HT9425 23 NFRP EHDA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Exploration-Hypothesis Development" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on May 22, 2023.
- Applicants must submit their applications by Aug 25, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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