NIDDK Central Repository Non-renewable Sample Access (X01 Clinical Trial Not Allowed) | PAR 22 171

Opportunity Information: Apply for PAR 22 171

The NIDDK Central Repository Non-renewable Sample Access opportunity (PAR 22-171) is a National Institutes of Health discretionary grant mechanism designed to help researchers gain access to scarce, non-renewable biospecimens and related data stored in the NIDDK Central Repositories. These repositories contain biological samples and accompanying datasets collected from numerous large, well-characterized clinical studies supported by NIDDK, making them a major resource for investigators who want to pursue new scientific questions without having to launch an entirely new cohort or trial. The key focus of this opportunity is enabling high-value secondary research using existing samples that cannot be replaced once used up, which is why access is managed carefully and requires clear justification and planning.

A central requirement is that applicants must first confirm that the specific samples they want are actually available. The program requires a formal sample availability report from the NIDDK Central Repositories documenting what can be provided, and applicants must include that report as part of the application package. In practical terms, the process starts with exploring what studies and specimen types exist through the repository website (https://repository.niddk.nih.gov), identifying the target study or studies, and working with the repository to verify inventory and feasibility before submitting the request through this funding mechanism. Because the samples are non-renewable, proposals typically need to make a strong case that the planned analyses are scientifically compelling, efficient in their use of limited material, and aligned with the consent and governance rules attached to the original collections.

The funding announcement is explicitly labeled "Clinical Trial Not Allowed," meaning it is not intended to support the conduct of new interventional clinical trials or prospective human subject interventions. Instead, it supports research activities centered on analyzing existing stored specimens and associated clinical data from prior studies. This is particularly relevant for biomarker discovery and validation, genetics and genomics, proteomics, metabolomics, assay development and testing, and other laboratory or computational analyses that can extract new insights from previously collected materials while respecting the limits of sample volume and availability.

Eligibility is broad and includes many types of U.S. organizations and some non-U.S. entities. Eligible applicants span state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other organizations. The announcement also calls out additional eligible groups, including Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); eligible federal agencies; faith-based or community-based organizations; Hispanic-serving institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American tribal governments other than federally recognized; tribally controlled colleges and universities (TCCUs); regional organizations; U.S. territories or possessions; and non-domestic (non-U.S.) entities/foreign organizations. This broad eligibility is meant to widen access to these unique materials across academia, government, nonprofit research, and industry, while still applying the repositorys oversight standards.

Key administrative details from the source record include the agency (National Institutes of Health), the activity category (Food and Nutrition, Health), and the CFDA number 93.847. The original closing date listed is June 26, 2025. The listing does not specify an award ceiling or expected number of awards in the provided fields, which suggests applicants should consult the full announcement and NIH guidance for current budgetary and programmatic constraints, as those details can vary by year and by the scope of the requested access and analyses.

Overall, this opportunity is best viewed as a pathway to responsibly access rare, high-quality clinical-study biospecimens and data for secondary research, with the repositories acting as the gatekeeper to ensure availability, appropriate use, and protection of a limited, irreplaceable scientific resource.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "NIDDK Central Repository Non-renewable Sample Access (X01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
• This funding opportunity was created on 2022-06-29.
• Applicants must submit their applications by 2025-06-26. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 22 171

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