Opportunity Information: Apply for PAR 23 319
This funding opportunity, PAR 23-319, is an NIH R01 grant (clinical trial optional) focused on implementation research to reduce major noncommunicable disease (NCD) risk factors in city environments. It is being offered by participating NIH Institutes and Centers in collaboration with the Global Alliance for Chronic Diseases (GACD). The central aim is not to invent entirely new clinical treatments, but to generate practical, real-world evidence on how to get proven interventions, policies, tools, and guidelines adopted and sustained where they are most needed, especially in settings where social and structural barriers make prevention and long-term management difficult.
The FOA targets two broad population contexts: (1) people living in World Bank-defined low- and middle-income countries (LMICs), and (2) American Indian/Alaska Native (AI/AN) Tribal Nation populations living in cities in the United States. A key feature is its emphasis on city environments, using a broad definition of "cities" that includes formal urban centers as well as informal settlements, slums, and peri-urban areas. In practice, that means applications can focus on the full range of urban living conditions that shape NCD risk, including overcrowding, food environments, transport systems, occupational exposures, housing conditions, access to preventive services, and the local policy landscape.
The research encouraged under this announcement is implementation-focused, meaning it prioritizes studying how evidence-based NCD risk-reduction strategies can be successfully delivered, adapted, integrated into existing systems, scaled up beyond pilot programs, and sustained over time. The FOA explicitly calls for work that identifies and addresses barriers to uptake, whether those barriers are at the level of individuals, communities, health systems, local governance, or broader policy and economic constraints. It also welcomes studies that strengthen dissemination and implementation science itself, such as developing or refining methods and measures that can be used to evaluate implementation success in diverse city settings and among disadvantaged populations.
From a topic standpoint, the FOA is framed around "risk factors for common NCDs" rather than a single disease category, which typically includes major, modifiable drivers such as unhealthy diet, physical inactivity, tobacco use, harmful alcohol use, and related cardiometabolic risks like obesity and hypertension. In the spirit of GACD and NIH implementation priorities, the work is expected to produce actionable findings that policymakers, health departments, tribal organizations, community practitioners, and health systems can use to improve prevention and/or management outcomes, particularly where inequities and limited resources make standard approaches less effective.
Eligibility is broad and designed to support cross-sector and community-engaged implementation research. Eligible applicants include various levels of government (state, county, city/township, special districts), independent school districts, public and private institutions of higher education, federally recognized Native American tribal governments, tribal organizations that are not federally recognized governments, public housing and Indian housing authorities, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses. The FOA also highlights additional eligible applicant types such as faith-based and community-based organizations, historically Black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, Asian American Native American Pacific Islander serving institutions (AANAPISIs), tribally controlled colleges and universities (TCCUs), regional organizations, eligible federal agencies, U.S. territories or possessions, and non-U.S. entities (foreign organizations), reflecting the global and community-centered nature of the work.
Administratively, this is a discretionary NIH grant opportunity under the R01 mechanism, with clinical trials allowed but not required ("clinical trial optional"), which gives applicants flexibility to propose rigorous implementation studies that may or may not include intervention testing in human participants. The CFDA numbers associated with this opportunity include 93.113, 93.242, 93.853, 93.865, 93.866, 93.867, and 93.989. The original closing date listed for the opportunity is 2024-03-11, and the posting date (creation date) is 2023-12-12. The award ceiling and expected number of awards are not specified in the provided source data, which is common for NIH announcements where budgets depend on project scope, institute participation, and available funds.
Overall, the opportunity is designed for teams that can bridge public health evidence with on-the-ground realities in urban and peri-urban settings, including strong partnerships with communities, health systems, and decision-makers. Competitive applications will typically align with the FOA by focusing on real implementation challenges (not just efficacy), using appropriate implementation frameworks and outcomes, and producing results that can guide scale-up and sustainability for NCD risk reduction among disadvantaged city populations in LMICs and/or AI/AN communities in U.S. urban environments.Apply for PAR 23 319
- The National Institutes of Health in the environment, health, income security and social services sector is offering a public funding opportunity titled "Implementation Research on Noncommunicable Disease Risk Factors among Low- and Middle-Income Country and Tribal Populations Living in City Environments (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.242, 93.853, 93.865, 93.866, 93.867, 93.989.
- This funding opportunity was created on 2023-12-12.
- Applicants must submit their applications by 2024-03-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is PAR 23-319?
PAR 23-319 is an NIH funding opportunity announcement (FOA) using the R01 grant mechanism (clinical trial optional). It supports implementation research focused on reducing major noncommunicable disease (NCD) risk factors in city environments, offered by participating NIH Institutes and Centers in collaboration with the Global Alliance for Chronic Diseases (GACD).
What is the main purpose of this funding opportunity?
The primary goal is to generate practical, real-world evidence on how to adopt, integrate, scale, and sustain proven interventions, policies, tools, and guidelines that reduce NCD risk factors in urban settings. The focus is on improving implementation where social and structural barriers make prevention and long-term management difficult, rather than inventing entirely new clinical treatments.
Is this FOA focused on developing new treatments?
No. The central emphasis is on implementing and sustaining evidence-based strategies (interventions, policies, tools, guidelines) in real-world settings, especially where uptake is hindered by community, system, governance, or policy barriers.
What kind of research does the FOA prioritize?
The FOA prioritizes implementation-focused research, including studying how proven NCD risk-reduction strategies can be delivered, adapted for local contexts, integrated into existing systems, scaled beyond pilot efforts, and sustained over time.
What populations and settings are targeted?
The FOA targets two broad contexts: (1) people living in World Bank-defined low- and middle-income countries (LMICs), and (2) American Indian/Alaska Native (AI/AN) Tribal Nation populations living in cities in the United States.
Does the project have to take place in a "city"?
Yes, the FOA emphasizes city environments and uses a broad definition of "cities." This includes formal urban centers as well as informal settlements, slums, and peri-urban areas.
What types of urban conditions can be addressed in proposed research?
Applications may focus on a wide range of urban living conditions that influence NCD risk, such as overcrowding, food environments, transport systems, occupational exposures, housing conditions, access to preventive services, and the local policy landscape.
What NCD risk factors are in scope?
The FOA is framed around "risk factors for common NCDs" and commonly includes major modifiable drivers such as unhealthy diet, physical inactivity, tobacco use, harmful alcohol use, and related cardiometabolic risks like obesity and hypertension.
Does the FOA focus on one specific disease area?
No. It is organized around NCD risk factors rather than a single disease category, supporting work that can drive prevention and/or management improvements through risk reduction.
What does "implementation research" mean in this FOA?
In this context, implementation research means studying how to successfully get evidence-based NCD risk-reduction strategies adopted and sustained in real-world city settings. This includes understanding and overcoming barriers to uptake and assessing implementation success using appropriate frameworks and outcomes.
What kinds of barriers does the FOA expect applicants to address?
The FOA explicitly calls for identifying and addressing barriers to uptake at multiple levels, including individuals, communities, health systems, local governance, and broader policy and economic constraints.
Are studies to improve dissemination and implementation (D&I) methods encouraged?
Yes. The FOA welcomes studies that strengthen dissemination and implementation science itself, such as developing or refining methods and measures used to evaluate implementation success in diverse city settings and among disadvantaged populations.
Who is the intended audience for the findings?
Projects are expected to produce actionable findings that can be used by policymakers, health departments, tribal organizations, community practitioners, and health systems, particularly in settings affected by inequities and limited resources.
What is the grant mechanism for this opportunity?
This is an NIH R01 grant opportunity (discretionary), which typically supports substantial research projects and multi-year efforts aligned with the FOA goals.
Are clinical trials required?
No. The FOA is "clinical trial optional," meaning clinical trials are allowed but not required. Applicants may propose rigorous implementation studies that may or may not include intervention testing in human participants.
Which organizations are eligible to apply?
Eligibility is broad. Eligible applicants include state, county, and city/township governments; special districts; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those that are not federally recognized governments); public housing and Indian housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); and small businesses.
Are community-based and faith-based organizations eligible?
Yes. The FOA highlights faith-based and community-based organizations as eligible applicants, reflecting the community-centered nature of implementation research.
Are minority-serving and tribally controlled institutions included as eligible applicants?
Yes. The FOA highlights eligibility for organizations such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, and tribally controlled colleges and universities (TCCUs).
Can non-U.S. entities apply?
Yes. The FOA indicates that non-U.S. entities (foreign organizations) are eligible, consistent with the global focus on LMIC city environments.
Are U.S. territories or possessions eligible?
Yes. The FOA lists U.S. territories or possessions among eligible applicant types.
Are federal agencies eligible to apply?
Yes. The FOA includes eligible federal agencies among the eligible applicant types.
Is the award ceiling listed?
No. The award ceiling is not specified in the provided information, which is common for NIH announcements where budgets depend on scope, participating institutes, and available funds.
Is the expected number of awards listed?
No. The expected number of awards is not specified in the provided information.
What are the CFDA numbers associated with this opportunity?
The CFDA numbers listed for this opportunity are 93.113, 93.242, 93.853, 93.865, 93.866, 93.867, and 93.989.
What is the posting date for this FOA?
The posting (creation) date provided is 2023-12-12.
What is the closing date for this FOA?
The original closing date listed is 2024-03-11.
What types of partnerships fit the goals of this FOA?
The opportunity is designed for teams that can bridge public health evidence with on-the-ground realities, typically involving strong partnerships with communities, health systems, and decision-makers in urban and peri-urban settings.
What makes an application align well with this FOA based on the description provided?
Based on the provided description, strong alignment generally includes focusing on real implementation challenges (not only efficacy), using appropriate implementation frameworks and outcomes, addressing barriers to uptake, and producing results that can inform scale-up and sustainability for NCD risk reduction among disadvantaged city populations in LMICs and/or AI/AN communities in U.S. urban environments.
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