Opportunity Information: Apply for W81XWH 18 CTRR CTA
The DoD Psychological Health/Traumatic Brain Injury, Complex Traumatic Brain Injury Rehabilitation Research, Clinical Trial Award (FY18 PH/TBIRP CTRR-CTA; Funding Opportunity Number W81XWH 18 CTRR CTA) is a Department of Defense research funding opportunity run through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed to move the field of traumatic brain injury rehabilitation forward by supporting clinical trials that test cognitive rehabilitation approaches, with an emphasis on practical impact for military and Veteran populations. Although the research is expected to translate to the broader public, proposals must clearly connect to the needs of active duty Service members, Veterans, and their beneficiaries.
The central purpose of this mechanism is to fund small, Phase I clinical trials focused on cognitive rehabilitation interventions after TBI. In this context, the award is meant to advance both knowledge and tangible rehabilitation-related products or practices that can restore function and improve outcomes after brain injury. The opportunity is specifically aimed at generating evidence on whether an intervention works, how well it works, and for whom, rather than purely exploratory or basic science studies. The program’s scope is cognitive rehabilitation, so the interventions under study should be intended to remediate or compensate for cognitive impairments and related functional problems that can follow TBI.
Priority areas include addressing cognitive deficits such as memory problems, slowed processing speed, impaired executive functioning, difficulty learning new information, attention deficits, and cognitive-communication challenges. The expectation is that funded trials will evaluate either novel rehabilitation approaches or standard-of-care interventions (or both) and produce outcomes that inform clinical practice. The program also signals strong interest in research that tackles real-world participation barriers for Service members with TBI, especially obstacles that interfere with return to duty as well as return to work or school. In other words, beyond showing changes on neuropsychological tests, proposed studies are encouraged to demonstrate meaningful functional improvement that matters in daily life and occupational roles.
Another key feature is the encouragement of pragmatic clinical trial designs. Rather than tightly controlled trials that are difficult to replicate in real clinics, the DoD is pushing applicants toward studies that reflect real-world conditions: comparing novel interventions against existing standard care, recruiting diverse but militarily relevant participants, and enrolling patients across different practice environments. The opportunity explicitly encourages recruitment from heterogeneous settings, including Department of Defense and Department of Veterans Affairs sites, and it highlights the value of partnering with federal rehabilitation research collaborators. Applicants are also encouraged to collect outcomes across a broad range of functioning and to incorporate standard-of-care DoD outcome measures where appropriate, so results are comparable and usable within military health systems.
From an administrative standpoint, this is a discretionary funding opportunity that can be awarded as a grant or cooperative agreement under the Science and Technology/Research and Development category (CFDA 12.420). Eligibility is listed as unrestricted, meaning the competition is open to a wide range of organization types, as long as any additional eligibility conditions in the full announcement are met. The opportunity was originally posted on August 15, 2018, with an original closing date of December 17, 2018, and it anticipated making about two awards. The award ceiling is listed as 0 in the summary data, which usually indicates that applicants need to refer to the full solicitation for budget guidance, limits, and any cost or scope expectations.
Overall, this award targets early-stage clinical trial evidence for cognitive rehabilitation after TBI, with a strong “military relevance first” requirement and a clear preference for trials that are practical, comparative, and clinically meaningful. The ideal application would propose a feasible Phase I clinical trial that tests a cognitive rehabilitation intervention in DoD and/or VA-related populations, measures outcomes that align with functional recovery and participation (including return-to-duty or similar milestones), and produces findings that can realistically be implemented across military and Veteran healthcare settings while also benefiting civilians with TBI.Apply for W81XWH 18 CTRR CTA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Psychological Health/ Traumatic Brain Injury, Complex Traumatic Brain Injury Rehabilitation Research, Clinical Trial Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Aug 15, 2018.
- Applicants must submit their applications by Dec 17, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD PH/TBIRP Complex Traumatic Brain Injury Rehabilitation Research, Clinical Trial Award (FY18 PH/TBIRP CTRR-CTA)
What is this funding opportunity?
This is the Department of Defense (DoD) Psychological Health/Traumatic Brain Injury Research Program (PH/TBIRP) Complex Traumatic Brain Injury Rehabilitation Research, Clinical Trial Award (FY18 PH/TBIRP CTRR-CTA), Funding Opportunity Number W81XWH 18 CTRR CTA. It is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) and supports clinical trials intended to advance traumatic brain injury (TBI) rehabilitation.
What is the main goal of this award?
The central goal is to move the field of TBI rehabilitation forward by funding small, Phase I clinical trials that test cognitive rehabilitation interventions. The emphasis is on generating early-stage clinical trial evidence that informs practice and produces tangible rehabilitation-related products or approaches that restore function and improve outcomes after brain injury.
What type of studies does the program want to fund?
The program is focused on clinical trials that evaluate cognitive rehabilitation interventions after TBI. The intent is to generate evidence about whether an intervention works, how well it works, and for whom, rather than supporting purely exploratory, observational, or basic science studies.
What is meant by "cognitive rehabilitation" in this opportunity?
In this context, cognitive rehabilitation refers to interventions designed to remediate (improve) or compensate for cognitive impairments and related functional difficulties that can occur after TBI. The intervention should be aimed at improving cognitive functioning and/or the real-world impacts of cognitive impairment.
Which cognitive problems are considered within scope?
Priority areas include cognitive deficits such as memory problems, slowed processing speed, impaired executive functioning, difficulty learning new information, attention deficits, and cognitive-communication challenges.
Are both novel and standard-of-care approaches allowed?
Yes. The opportunity anticipates trials that evaluate novel rehabilitation approaches and/or standard-of-care interventions (or both), with outcomes that can inform clinical practice.
How important is military relevance?
Military relevance is a core requirement. While the research is expected to translate to the broader public, proposals must clearly connect to the needs of active duty Service members, Veterans, and their beneficiaries.
Who is the intended beneficiary population?
The opportunity prioritizes impact for active duty Service members, Veterans, and their beneficiaries who are affected by TBI and related cognitive and functional challenges.
Does the program care about functional outcomes beyond test scores?
Yes. The program encourages studies that show meaningful functional improvement in real life, not only changes on neuropsychological tests. It specifically highlights the importance of outcomes connected to participation and daily functioning, including return to duty and also return to work or school.
What kinds of real-world barriers is the program interested in addressing?
There is strong interest in research that tackles practical participation barriers for Service members with TBI, particularly obstacles that interfere with return to duty, and more broadly barriers that affect return to work or school.
What is a "pragmatic clinical trial design" as described here?
The opportunity encourages pragmatic trial designs that reflect real-world clinical conditions and are easier to replicate in routine practice. Examples described include comparing a novel intervention against existing standard care, recruiting diverse but militarily relevant participants, and enrolling patients across different practice environments.
Are multi-site or heterogeneous recruitment settings encouraged?
Yes. The opportunity explicitly encourages recruitment from heterogeneous settings and notes DoD and Department of Veterans Affairs (VA) sites as examples of relevant environments.
Does the opportunity encourage collaboration with federal partners?
Yes. It highlights the value of partnering with federal rehabilitation research collaborators.
Are there expectations around outcome measures?
Applicants are encouraged to collect outcomes across a broad range of functioning. The opportunity also encourages incorporating standard-of-care DoD outcome measures where appropriate so results are comparable and useful within military health systems.
What phase of clinical trials is this mechanism intended to support?
This mechanism is intended to support small, Phase I clinical trials focused on cognitive rehabilitation interventions after TBI.
Is this opportunity a grant or a cooperative agreement?
It is described as a discretionary funding opportunity that can be awarded as a grant or a cooperative agreement.
What is the administering agency?
The opportunity is run through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Department of Defense PH/TBIRP program area described in the summary.
What is the CFDA number and funding category?
The opportunity is listed under CFDA 12.420 and falls within the Science and Technology/Research and Development funding category.
Who is eligible to apply?
Eligibility is listed as unrestricted in the summary, meaning a wide range of organization types may apply, as long as any additional eligibility conditions in the full announcement are met.
How many awards were anticipated?
The opportunity anticipated making about two awards.
What were the posting and closing dates shown in the summary?
The opportunity was originally posted on August 15, 2018, with an original closing date of December 17, 2018.
Is there a funding ceiling or budget cap provided in the summary?
The award ceiling is listed as 0 in the summary data, which typically indicates that applicants need to consult the full solicitation for budget guidance, limits, and any cost or scope expectations.
What makes a strong application based on this description?
An ideal application would propose a feasible Phase I clinical trial that tests a cognitive rehabilitation intervention relevant to DoD and/or VA-related populations, demonstrates clear military relevance, measures outcomes tied to functional recovery and participation (including return-to-duty or similar milestones), and produces findings that could realistically be implemented across military and Veteran healthcare settings (with expected broader benefit to civilians with TBI as well).
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